反应详情

To a solution 3-aminopyrazine-2-carboxamide (3 g, 22 mmol) in acetic acid (25 mL) was drop wise added bromine (4.2 g, 26.5 mmol) at room temperature the reaction mixture was stirred for 0.5 h and Na2CO3 (2 eq) was added slowly. Upon added of the reaction, the solvent was removed in vacuo, water (50 mL) was added to the residue and the precipitate was collected on a filter and washed with hexane (50 mL) to give 3-amino-6-bromopyrazine-2-carboxamide (4.5 g) as a yellow solid: MS (EI) for C5H5BrN4O: 217 (MH+).

1. customat room temperature
2. additionUpon added of the reaction
3. customthe solvent was removed in vacuo, water (50 mL)
4. additionwas added to the residue
5. customthe precipitate was collected on
6. filtrationa filter
7. washwashed with hexane (50 mL)