HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(1-oxo-4-ethoxycarbonylbutyl)-N-(3-pyridyl)indole → 3-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(1-oxo-4-ethoxycarbonylbutyl)-N-(3-pyridyl)indole | HCID 13672696 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 3-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole | HCID 13672697 | — |
Reaction Steps
A mixture of 15.0 of 3-(1-oxo-4-ethoxycarbonylbutyl)-N-(3-pyridyl)indole, 100 ml of 0.5N sodium hydroxide is heated under reflux for 16 hours. The solution is acidified to pH of about 6 with hydrochloric and extracted with methylene chloride. The methylene chloride extract is dried over sodium sulfate and evaporated to dryness to give 3-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole, melting point 177°-178°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04609733 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-bac6c13fde434d098a681ccd1fde0d81 |
| Source note | uspto-grants-1986_09 |