Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 6-Bromo-2,2-dimethyl-1-hexanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Lithium borohydride | HCID 4148881 | — |
| 반응물 | Ethyl 6-bromo-2,2-dimethylhexanoate | HCID 10444833 | — |
| 반응물 | 6-Bromo-2-methyl-2-p-tolylhexan-1-ol | HCID 11196892 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 6-Bromo-2,2-dimethyl-1-hexanol | HCID 10035985 | 99% |
반응 단계
According to the procedure described for the synthesis of 206e (Ackerley, N. et al. J. Med. Chem. 1995, 38, 1608-1628; Manley, P. W. et al. J. Med. Chem. 1987, 30, 1812-1818), 205c (500.0 g, 2.0 mol) was reacted with LiBH4 (65.0 g, 3.0 mol) and methanol (95.0 g, 3.0 mol) in CH2Cl2 (6.0 L) to afford 206c (417.0 g, 99%) as an oil. 1H NMR (CDCl3): δ 3.38 (t, 2H, J=7.4), 3.50-3.40 (br. s, 1H, OH), 3.22 (d, 2H, J=5.6), 1.85 (qv, 2H, J=7.4), 1.50-1.35 (m, 2H), 1.30-1.20 (m, 2H), 0.85 (s, 6H). 13C NMR (CDCl3) δ 71.4, 37.5, 34.9, 33.9, 33.4, 23.7, 22.4.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07705177B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-98ddaa35ed6a4357afd26f3454bdbfc8 |
| 출처 메모 | uspto-grants-2010_04 |