反应详情

温度

125 °C

A mixture of 150 mg (0.623 mmol) 1-(5-chloro-2-nitro-phenyl)-piperidine (as prepared in the previous step) and 272 μL (3.12 mmol) of morpholine were heated with stirring under Ar at 125° C. for 84 h. After cooling to rt, the mixture was poured into water (40 mL) and extracted with EtOAc (2×20 mL). The combined extracts were washed with water (2×10 mL) and brine (10 mL) and then dried (Na2SO4) Concentration afforded 162 mg (89%) of the title compound as an orange resin: Mass spectrum (ESI, m/z): Calcd. for C15H21N3O3, 292.2 (M+H), found 292.1.

1. temperaturewere heated
2. temperatureAfter cooling to rt
3. extractionextracted with EtOAc (2×20 mL)
4. washThe combined extracts were washed with water (2×10 mL) and brine (10 mL)
5. customdried
6. concentration(Na2SO4) Concentration