Potassium Carbonate → 4-(3-Nitro-4-piperidin-1-yl-phenyl)-morpholine

Participants

Reaction Steps

The title compound was prepared following the procedure of Example 10, step (b) using 152 mg (0.687 mmol) of 3-nitro-4-piperidin-1-yl-phenylamine (as prepared in Example 10, step (a)), 78.6 mg (0.625 mmol) of 2-bromoethyl ether and 433 mg (3.13 mmol) of anh K2CO3 except the mixture was heated to reflux in 2 mL of toluene for 20 h. Chromatography on a 10-g silica SPE column with 40% Et2O-hexane afforded 128 mg (70%) of the title compound as a dark orange resin: Mass spectrum (ESI, m/z): Calcd. for C15H21N3O2, 292.2 (M+H), found 292.1.

Provenance & Evidence