1-(2-Hydroxyethyl)piperazine → 2-{4-[3-(4-Methyl-piperidin-1-yl)-4-nitro-phenyl]-piperazin-1-yl}-ethanol

Participants

Reaction Steps

The procedure of Example 4, step (b) was followed using 810 mg (3.18 mmol) of 1-(5-chloro-2-nitro-phenyl)-4-methyl-piperidine (as prepared in the Example 12, step (a)) and 1.95 mL (15.9 mmol) of 1-(2-hydroxyethyl)piperazine for 14 h to afford 1.11 g (100%) of the title compound as a yellow solid: Mass spectrum (ESI, m/z): Calcd. for C18H28N4O3, 349.2 (M+H), found 349.2.

Provenance & Evidence