Methylamine → N-methyl-(4-nitro-3-piperidin-1-yl-phenyl)-amine

HRID 646880노트

반응식

HRID 646880 반응식
F[C:2]1[CH:3]=[CH:4][C:5]([N+:14]([O-:16])=[O:15])=[C:6]([N:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[CH:7]=1.[CH3:17][NH2:18]>CO>[CH3:17][NH:18][C:2]1[CH:3]=[CH:4][C:5]([N+:14]([O-:16])=[O:15])=[C:6]([N:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[CH:7]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 532567081-(5-Fluoro-2-nitrophenyl)piperidine

생성물 1

HCID 68680582N-methyl-(4-nitro-3-piperidin-1-yl-phenyl)-amine수율 100%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 1-(5-fluoro-2-nitro-phenyl)-piperidine (200 mg, 0.89 mmol) in 4 mL of 2M methylamine in MeOH was heated in a sealed tube for 12 h at 80° C. Removal of the solvent under vacuum afforded methyl-(4-nitro-3-piperidin-1-yl-phenyl)-amine (209 mg, 100%). Mass spectrum (ESI, m/z): Calcd for C12H17N3O2, 236.1 (M+H), found 236.1.

후처리

  1. customRemoval of the solvent under vacuum

출처 및 근거

ORD 기록
ord-d0b88e6e0f2a4326bc862418ee24a925
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07705042B2

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