反应详情

温度

65 °C

To a mixture of 245 g. (2 moles) of 3,5-dimethylphenol and 2 liters of 2N sodium hydroxide was added 2.5 moles of 1,4-dichlorobutanol with stirring at 65° C. overnight. The solid precipitate which separated on cooling was filtered and washed with water to neutrality. Recrystallization with isopropyl ether yielded 375 g. of white crystalline solid which melted at 74°-76° C.

1. additionTo a mixture of 245 g
2. customThe solid precipitate which separated
3. temperatureon cooling
4. filtrationwas filtered
5. washwashed with water to neutrality
6. customRecrystallization with isopropyl ether
7. customyielded 375 g