Sodium Hydroxide → 1-(2-Trimethylsilanyl-ethoxymethyl)-1h-imidazole-4-carboxylate sodium salt

HRID 646901Notes

Reaction equation

HRID 646901 reaction equation
C[O:2][C:3]([C:5]1[N:6]=[CH:7][N:8]([CH2:10][O:11][CH2:12][CH2:13][Si:14]([CH3:17])([CH3:16])[CH3:15])[CH:9]=1)=[O:4].[OH-].[Na+:19]>CO>[Na+:19].[CH3:15][Si:14]([CH3:17])([CH3:16])[CH2:13][CH2:12][O:11][CH2:10][N:8]1[CH:9]=[C:5]([C:3]([O-:4])=[O:2])[N:6]=[CH:7]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22954042Methyl 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylate

Product 1

HCID 686823391-(2-Trimethylsilanyl-ethoxymethyl)-1h-imidazole-4-carboxylate sodium saltYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-4-carboxylic acid methyl ester (0.42 g, 1.6 mmol) (as prepared in Example 40, step (a)) in MeOH (3.0 mL) was added 1N NaOH (1.6 mL) and mixture was stirred for 8 h at RT. The reaction was concentrated to give 0.43 g (100%) of the title compound as a white solid. Mass spectrum (ESI, m/z): Calcd. for C10H18N2O3Si, 243.1 (M+H), found 243.1.

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-32439e82116e49918de0aaef1bbf08eb
Source dataset
uspto-grants-2010_04
Patent number
US07705042B2

Reaction notes

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