Potassium Carbonate → HCID 58638517, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3,5-dichloro-2-nitropyridine (193 mg, 1.00 mmol), 4-methylpiperidine (118 μL, 1.00 mmol) and K2CO3 (138 mg, 1.00 mmol) in toluene (10 mL) was heated at 50° C. for 3 h. Toluene was removed in vacuo and the residue obtained was purified on silica (2% EtOAc/hexane) to obtain the title compound (153 mg, 60%). 1H-NMR (CDCl3; 400 MHz): δ 7.95 (s, 1H, J=2.5 Hz), 7.58 (s, 1H, J=2.5 Hz), 3.30 (m, 2H), 2.95 (m, 2H), 1.87 (m; 2H), 1.65 (m, 1H), 1.35 (m, 2H), 1.0 (d, 3H, J=6.3 Hz).

Provenance & Evidence