1-Methylpiperazine → HCID 58638509, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5′-chloro-4-methyl-2′-nitro-3,4,5,6-tetrahydro-2H-[1,3′]bipyridinyl (as prepared in the previous step) (255 mg, 1.00 mmol) in DMF (10 mL) was added 1-methyl piperazine (110 μL, 1.00 mmol). The resulting mixture was heated at 125° C. overnight. The reaction mixture was allowed to cool to room temperature and partitioned between water and EtOAc. The EtOAc layer was separated, dried (Na2SO4) and concentrated in vacuo. The residue obtained was purified on silica (10-50% EtOAc:hexane) to obtain the title compound (204 mg, 64%). 1H-NMR (CDCl3; 400 MHz): δ 7.67 (d, 1H, J=2.52 Hz), 6.69 (d, 1H, J=2.52 Hz), 3.39 (m, 4H), 3.29 (m, 2H), 2.75 (m, 2H), 2.56 (m, 4H), 2.35 (s, 3H), 1.71 (m, 2H), 1.6-1.5 (m, 3H), 0.99 (d, 3H, J=6.3 Hz).

Provenance & Evidence