反应详情

5.56 g (99 mmol) KOH flakes were dissolved in 6.82 ml water and 13.65 ml ethanol and then treated with 11.12 g (28.34 mmol) of dibenzyl 2-(3,4,4-trifluoro-3-butenyl)-malonate. After heating under reflux for 4 hours, the reaction mixture was poured into 30 ml water and washed with ether. The aqueous phase was acidified with dilute hydrochloric acid and extracted 4 times with ether. The organic phase was dried over sodium sulphate, filtered and then concentrated in a rotary evaporator.

1. temperatureAfter heating
2. temperatureunder reflux for 4 hours
3. washwashed with ether
4. extractionextracted 4 times with ether
5. dry with materialThe organic phase was dried over sodium sulphate
6. filtrationfiltered
7. concentrationconcentrated in a rotary evaporator