HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → N-(tert-Butoxycarbonyl)-L-tyrosyl-D-methionylglycine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Boc-Tyr-D-Met-Gly-OMe | HCID 13216983 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | N-(tert-Butoxycarbonyl)-L-tyrosyl-D-methionylglycine | HCID 12919645 | — |
Reaction Steps
The title compound of Example 3 (12.6 g., 26 mmoles) is dissolved in 78 ml. of methanol and 78 ml of 1 N sodium hydroxide is added dropwise with stirring to give a clear solution. After 1/2 hour, the tlc (5 percent methanol-chloroform) showed that saponification was complete.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04407746 |
| Source dataset | uspto-grants-1983_10 |
| ORD ID | ord-0d5d9f80418e4e99bde050a5fdbf73e6 |
| Source note | uspto-grants-1983_10 |