HCID 13120355, compound → 1-(2-Ethoxyphenoxy)-4-phthalimido-2-butanol

HRID 64702Notes

Reaction equation

HRID 64702 reaction equation
[CH2:1]([O:3][C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[O:6][CH2:7][CH:8]([OH:12])[CH2:9][CH2:10]Cl)[CH3:2].[C:17]1(=[O:27])[NH:21][C:20](=[O:22])[C:19]2=[CH:23][CH:24]=[CH:25][CH:26]=[C:18]12.[K]>>[CH2:1]([O:3][C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[O:6][CH2:7][CH:8]([OH:12])[CH2:9][CH2:10][N:21]1[C:20](=[O:22])[C:19]2=[CH:23][CH:24]=[CH:25][CH:26]=[C:18]2[C:17]1=[O:27])[CH3:2]

Participants

3

Reactant 2

HCID 13120355HCID 13120355, compoundHCID 24194345Phthalimide potassium salt

Product 1

HCID 131204791-(2-Ethoxyphenoxy)-4-phthalimido-2-butanol

Procedure

A mixture of 30 g. (0.12 mole) of 1-(2-ethoxyphenoxy)-4-chloro-2-butanol and 18.5 g. (0.10 mole) of potassium phthalimide was heated slowly to 130° C. for 10 min. and at 160° C. for one hour with stirring. The reaction mixture was extracted with 250 ml. of hot toluene. A crystalline solid separated from the toluene extract when cooled to room temperature. The solid was recrystallized from toluene and melted at 93°-95° C.

Workup

  1. additionA mixture of 30 g
  2. extractionThe reaction mixture was extracted with 250 ml
  3. customA crystalline solid separated from the toluene
  4. extractionextract when
  5. customThe solid was recrystallized from toluene and melted at 93°-95° C.

Sources & evidence

ORD record
ord-9e3fb65627e64bda85f99e2064f66d24
Source dataset
uspto-grants-1986_09
Patent number
US04609735

Reaction notes

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