2,3,5-Trimethylphenol → HCID 12906130, compound

Participants

Reaction Steps

2,3,5-Trimethylphenol (formula VII wherein R=H3C, H=H, Y=OH) (0.9 part), aluminum chloride (2.1 parts) and ethyl 6-chloroformylhexanoate (1.3 part) were treated as in Example (1) (1). The procedure provided colorless needles of ethyl 6-(2'-hydroxyl-3',4',6'-trimethylbenzoyl)hexanoate (formula II-1 wherein R=H3C, X=H, Y=OH, n=5, in the form of ethyl ester) (1.5 part) melting at 47°-48° C.

Provenance & Evidence