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0 °C

To a 100 ml Erlenmeyer flask equipped with a reflux condensor is added 2.54 gm of 3-pyridyl-2,4-dichlorophenylcarbinol and 30 ml of chloroform. The system is cooled to 0° C. and 1.31 gm (1.2 equivalents) of thionyl chloride in 25 ml of chloroform is added over 1/2-hour. After addition of the thionyl chloride, the system is allowed to come to room temperature and stirred there for 2 hours. The system is then heated at reflux for 1 hour. The chloroform is removed by stripping to give the alpha-chloro-alpha-(3-pyridyl)-2,4-dichlorotoluene hydrochloride salt.

1. customTo a 100 ml Erlenmeyer flask equipped with a reflux condensor
2. customto come to room temperature
3. temperatureThe system is then heated
4. temperatureat reflux for 1 hour
5. customThe chloroform is removed