HCID 123153128, compound → 6,6-Difluoro-5-trifluoromethyl-5-hexenol

HRID 6471Notes

Reaction equation

HRID 6471 reaction equation
[F:1][C:2]([F:18])=[C:3]([C:14]([F:17])([F:16])[F:15])[CH2:4][CH2:5][CH2:6][CH2:7][O:8][SiH2]C(C)(C)C>CO>[F:1][C:2]([F:18])=[C:3]([C:14]([F:15])([F:16])[F:17])[CH2:4][CH2:5][CH2:6][CH2:7][OH:8]

Participants

3

Reactant 1

HCID 123153128HCID 123153128, compound

Product 1

HCID 197938566,6-Difluoro-5-trifluoromethyl-5-hexenol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3.59 g (11.28 mmol) 6,6-difluoro-5-trifluoromethyl-1-tert-butylsilyloxy-5-hexene in 50 ml methanol was treated with a teaspoon full of ion exchange resin and the mixture stirred for 3 hours at room temperature. The ion exchange resin was then filtered off and washed with methanol. The filtrate was carefully concentrated in a rotary evaporator (bath temperature=35° C.; 200 mbar). The residue was used without further purification.

Workup

  1. filtrationThe ion exchange resin was then filtered off
  2. washwashed with methanol
  3. concentrationThe filtrate was carefully concentrated in a rotary evaporator (bath temperature=35° C.; 200 mbar)
  4. customThe residue was used without further purification

Sources & evidence

ORD record
ord-790e2a778f77438c9b5e15011df151a3
Source dataset
uspto-grants-1993_09
Patent number
US05248810

Reaction notes

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