Glycol monoethyl ether → Acetic acid, ((4-(4-methoxyphenyl)-2-thiazolyl)amino)oxo-, 2-ethoxyethyl ester

HRID 647124Notes

Reaction equation

HRID 647124 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([NH:14][C:15](=[O:19])[C:16]([OH:18])=[O:17])[S:12][CH:13]=2)=[CH:5][CH:4]=1.[CH2:20]([O:22][CH2:23][CH2:24]O)[CH3:21]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([NH:14][C:15](=[O:19])[C:16]([O:18][CH2:21][CH2:20][O:22][CH2:23][CH3:24])=[O:17])[S:12][CH:13]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 8076Glycol monoethyl etherHCID 12689383HCID 12689383, compound

Product 1

HCID 3067451Acetic acid, ((4-(4-methoxyphenyl)-2-thiazolyl)amino)oxo-, 2-ethoxyethyl ester

Procedure

Using a method similar to Example 12, 6.95 g of N-[4-(4-methoxyphenyl)-thiazol-2-yl]-oxamic acid and 5.6 g of ethylene glycol monoethyl ether give, after crystallization of the crude product from ethanol/active charcoal, 4 g of the compound of the formula I, with R1 =4--OCH3 --C6H4 and R2 =CH2CH2 --OC2H5, of melting point 130°-133° C.

Workup

  1. customgive
  2. customafter crystallization of the crude product from ethanol/active charcoal, 4 g of the compound of the formula I

Sources & evidence

ORD record
ord-94173b049c95430f97f5fe8a4df3a03f
Source dataset
uspto-grants-1983_10
Patent number
US04407810

Reaction notes

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