Sodium Iodide → HCID 20485542, compound

Participants

Reaction Steps

3,4-Dihydroxyphenacyl chloride (7 g) is added to a suspension of 5-(pyrrolidin-1-yl)-1,2-dithiol-3-thione (5.1 g) and sodium iodide (6.2 g) in acetone (90 cc), and the reaction mixture is kept under reflux for 1 hour. After cooling, the insoluble product is filtered off and washed successively with acetone (3×20 cc), with water (3×20 cc) and then with diethyl ether (3×20 cc). By recrystallisation of the resulting product from a dimethylformamide/methanol mixture (20/80 by volume; 600 cc) and then desolvation by stirring for 30 minutes in water (100 cc), N-[5-(3,4-dihydroxyphenacylthio)-1,2-dithiol-3-ylidene]-pyrrolidinium iodide hydrate (6.9 g), melting at about 130° C., is obtained.

Provenance & Evidence