Clenbuterol → HCID 13488797, compound

HRID 647144Notes

Reaction equation

HRID 647144 reaction equation
[NH2:1][C:2]1[C:15]([Cl:16])=[CH:14][C:5]([CH:6](O)[CH2:7][NH:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:4][C:3]=1[Cl:17].S(Cl)([Cl:20])=O>>[NH2:1][C:2]1[C:15]([Cl:16])=[CH:14][C:5]([CH:6]([Cl:20])[CH2:7][NH:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:4][C:3]=1[Cl:17]

Participants

3

Reactant 2

HCID 2783ClenbuterolHCID 24386Thionyl Chloride

Product 1

HCID 13488797HCID 13488797, compound

Procedure

Under N2 atmosphere, 27.72 g of 4-amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol is added to 200 ml of thionyl chloride stirred at 0°-5° C. After addition is completed, the reaction mixture is stirred at ambient temperature for 3 hours. Subsequently, the mixture is evaporated to dryness in vacuo to afford 37.34 g of yellow solid, which is used as is.

Workup

  1. additionAfter addition
  2. stirringthe reaction mixture is stirred at ambient temperature for 3 hours
  3. customSubsequently, the mixture is evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-5e4ce97cd8af461fa57d9a276134d822
Source dataset
uspto-grants-1983_10
Patent number
US04407819

Reaction notes

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