Sulfuric Acid → HCID 5360149, compound

HRID 647228Notes

Reaction equation

HRID 647228 reaction equation
S(=O)(=O)(O)O.S([O:16][C:17]1[C:22]([NH:23]S(C2C=CC(C)=CC=2)(=O)=O)=[CH:21][C:20]([CH3:34])=[C:19]([N+:35]([O-:37])=[O:36])[CH:18]=1)(C1C=CC(C)=CC=1)(=O)=O>O>[NH2:23][C:22]1[C:17]([OH:16])=[CH:18][C:19]([N+:35]([O-:37])=[O:36])=[C:20]([CH3:34])[CH:21]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 131713131HCID 131713131, compound

Product 1

HCID 5360149HCID 5360149, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 120 ml of stirring concentrated sulfuric acid at room temperature was added 12.0 g (0.0252 mol) of 5-nitro-2-p-toluenesulfonamido-p-cresol tosylate. Complete solution occurred without exotherm in 15 minutes. After stirring 11/2 hours the reaction was poured into 1500 ml of water and extracted with ethyl acetate. The organic layer was washed with aqueous sodium carbonate, dried over magnesium sulfate and concentrated under reduced pressure to yield 3.6 g (85 percent) of pure product as an orange solid.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with aqueous sodium carbonate
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-281e760d139d42a58073146e52ae3d8f
Source dataset
uspto-grants-1983_10
Patent number
US04407930

Reaction notes

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