Sulfuric Acid → trimethylpyruvic acid N-acetylamide

Participants

Reaction Steps

Firstly 25.6 g (0.25 mol) of acetic anhydride and then 27.8 g (0.25 mol) of pivaloyl cyanide were introduced, in each case at room temperature, into 49.0 g (0.5 mol) of initially introduced concentrated sulphuric acid. After the reaction mixture had been further stirred for 4 hours, 150 g of ice-water were added to it and it was thoroughly stirred. The precipitated reaction product was filtered off under suction, washed with 100 ml of water and dried. 37.0 g (86.5% of theory) of trimethylpyruvic acid N-acetylamide were obtained as colorless shiny platelets of melting point 82° to 84° C.

Provenance & Evidence