Potassium Hydroxide → 4-(1-Pyrrolyl)-1-indanol

HRID 647320Notes

Reaction equation

HRID 647320 reaction equation
C([O:4][CH:5]1[C:13]2[C:8](=[C:9]([N:14]3[CH:18]=[CH:17][CH:16]=[CH:15]3)[CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6]1)(=O)C.[OH-].[K+]>O.C(O)C>[N:14]1([C:9]2[CH:10]=[CH:11][CH:12]=[C:13]3[C:8]=2[CH2:7][CH2:6][CH:5]3[OH:4])[CH:15]=[CH:16][CH:17]=[CH:18]1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 132395804-(1-Pyrrolyl)-1-indanyl acetate

Product 1

HCID 131024614-(1-Pyrrolyl)-1-indanolYield 27%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

In the manner of Example 1, step H, hydrolysis of 13.0 g (0.054 mole) of 4-(1-pyrrolyl)-1-indanyl acetate with 4.3 g of potassium hydroxide in 77 mL of water and 154 mL of ethanol gave 2.9 g of 4-(1-pyrrolyl)-1-indanol, m.p. 80°-81° C.

Sources & evidence

ORD record
ord-3775fe0166e84891b4e38ff665684b89
Source dataset
uspto-grants-1983_10
Patent number
US04408057

Reaction notes

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