HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dimethylformamide → 1-Benzyl-4-(2-hydroxy-4-methoxybenzoyl)piperidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dimethylformamide | HCID 6228 | — |
| Edukt | Benzyl Bromide | HCID 7498 | — |
| Edukt | Sodium Bicarbonate | HCID 516892 | — |
| Edukt | (2-Hydroxy-4-methoxyphenyl)(piperidin-4-yl)methanone | HCID 13076390 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | 1-Benzyl-4-(2-hydroxy-4-methoxybenzoyl)piperidine | HCID 13076397 | 57,4% |
Reaktionsschritte
A mixture of 14.50 g of 4-(2-hydroxy-4-methoxybenzoyl)piperidine, 6.40 ml of benzyl bromide, 10.20 g of sodium bicarbonate and 74.0 ml of dimethylformamide was stirred at 60° for 15 hrs. The reaction mixture was poured into 250 ml of water and a precipitate formed. The precipitate was collected, washed with water and recrystallized from ethanol to yield 10.0 g (57.4%) of product, mp, 123°-125°.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04408054 |
| Quelldatensatz | uspto-grants-1983_10 |
| ORD ID | ord-9ee9d3539ad349d888f2330d44e3eee3 |
| Quellennotiz | uspto-grants-1983_10 |