Sodium borohydride → HCID 20252436, compound

HRID 647387Notes

Reaction equation

[Cl:1][C:2]1[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:22][C:3]=1[O:4][C:5]1[CH:21]=[CH:20][C:8]([O:9][CH:10]([CH3:19])[C:11](=[O:18])[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:7][CH:6]=1.[BH4-].[Na+]>>[Cl:1][C:2]1[CH:25]=[C:24]([C:26]([F:27])([F:29])[F:28])[CH:23]=[CH:22][C:3]=1[O:4][C:5]1[CH:21]=[CH:20][C:8]([O:9][CH:10]([CH3:19])[CH:11]([OH:18])[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:7][CH:6]=1

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 20252399HCID 20252399, compound

Product 1

HCID 20252436HCID 20252436, compound

Procedure

The process of Example 17 is repeated using ethyl 4-[4-(2chloro-4trifluoromethylphenoxy)phenoxy]-3-oxopentanoate (400 mg) and NaBH4 (100 mg) to give ethyl 4-[4-(2-chloro-4-trifluoromethylphenoxy)phenoxy]-3-hydroxypentanoate, MS m/e 432 (M+).

Sources & evidence

ORD record: ord-ec61afd962984c8e9e38508b65701511
Source dataset: uspto-grants-1983_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04408076

Reaction notes

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