反应详情

In 400 ml of chloroform was dissolved 78.9 g of 4-chloro-2-fluorophenyl isothiocyanate, and 68.6 g of 1-morpholino-1-cyclohexene was added dropwise to the solution with stirring over a 10-minute period. After stirring was continued at room temperature for 10 hours, the reaction mixture was concentrated under reduced pressure, and the residue was treated with a small amount of cold ethanol. The resulting crystals were collected by filtration, and there was obtained 127.9 g (yield of 86%) of the subject compound, m.p. 86°-88° C.

1. additionwas added dropwise to the solution
2. stirringAfter stirring
3. concentrationthe reaction mixture was concentrated under reduced pressure
4. additionthe residue was treated with a small amount of cold ethanol
5. filtrationThe resulting crystals were collected by filtration