反应详情

In 20 ml of ethanol was dissolved 3.0 g of 2-(4-chloro-2-fluorophenyl)-2,3,4,5,6,7-hexahydro-3-mercapto-1H-isoindol-1-one and 1.4 g of iodine was added to the solution, followed by stirring at room temperature for 5 hours. Upon cooling, there resulted crystals, which were recovered by filtration, washed with ethanol and dried, thereby producing 1.7 g (yield of 57%) of the subject compound. Recrystallization from acetone yielded white crystals, m.p. 146°-147° C.

1. additionwas added to the solution
2. temperatureUpon cooling
3. customthere resulted crystals, which
4. filtrationwere recovered by filtration
5. washwashed with ethanol
6. customdried