Potassium Hydroxide → HCID 20484902, compound

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Ethyl 2-{4-[N-(1-chloroisoquinolin-3-yl)-N-methylamino]phenoxy}propionate (2.87 g), in a solution of potassium hydroxide (0.42 g) in ethanol, was hydrogenated at atmospheric pressure over a palladium on carbon catalyst. After uptake of the theoretical amount of hydrogen the solution was filtered to remove the catalyst and the solvent was removed by distillation under reduced pressure. The product was purified by column chromatography over silical gel (eluant dichloromethane/ethylacetate; 99:1) to give ethyl 2-{4-[N-(isoquinolin-3-yl)-N-methylamino]phenoxy}propionate (0.38 g) as a green oil. The assigned structure was confirmed by proton magnetic resonance spectroscopy and mass spectrometry. Proton magnetic resonance spectrum (CDCl3 ; δ in ppm): 1.20 (3H, t); 1.60 (3H, d); 3.45 (3H, s); 4.20 (2H, q); 4.70 (1H, q); 6.60 (1H, s); 6.8-7.4 (7H, m); 7.65 (1H, d); 8.90 (1H, s).

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