Acetic Acid → HCID 13386235, compound

Participants

Reaction Steps

A mixture of 3-chloro-1-[N-(4-methoxyphenyl)amino]isoquinoline (1.90 g), hydrogen bromide (10 ml of 48%) and glacial acetic acid was heated under reflux for a period of 9.5 hours. The reaction mixture was poured into water, and the aqueous mixture was extracted with ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate and the solvent was removed by distillation under reduced pressure to give 4-[N-(3-chloroisoquinolin-1-yl)amino]phenol (1.84 g) as pale yellow crystals mp 170° C.

Provenance & Evidence