反应详情

A slight excess of ethanolic potassium hydroxide was added to a solution of ethyl 2-{4-[N-(1,7-dichloroisoquinolin-3-yl)-N-methylamino]phenoxy}propionate in ethanol at room temperature. The mixture was stirred for 12 hrs, then evaporated. The residue was diluted with water, acidified with dilute hydrochloric acid and extracted with dichloromethane. The dichloromethane extract was dried over sodium sulfate and then evaporated to give 2-{4-[N-(1,7-dichloroisoquinolin-3-yl)-N-methylamino]phenoxy}propionic acid as a yellow solid, mp 136° C.

1. customevaporated
2. additionThe residue was diluted with water
3. extractionextracted with dichloromethane
4. extractionThe dichloromethane extract
5. dry with materialwas dried over sodium sulfate
6. customevaporated