Potassium Carbonate → HCID 178472169, compound

Participants

Reaction Steps

A mixture of ethyl 2-bromopropionate (1.36 g), 4-[N-(1-hydroxyisoquinolin-3-yl)-N-methylamino]phenol (2.00 g), anhydrous potassium carbonate (1.04 g) and methyl ethyl ketone (20 ml) was heated under reflux for a period of 3 hours. The mixture was cooled, washed with water and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give an oil, which was purified by column chromatography over silica gel (eluant dichloromethane to yield ethyl 2-{4-[N-(1-hydroxyisoquinolin-3-yl)-N-methylamino]phenoxy}propionate (1.92 g) as a brown solid mp 96° C.

Provenance & Evidence