HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 20484930, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 13386227 | HCID 13386227 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 20484930 | HCID 20484930 | — |
Reaction Steps
A mixture of ethyl 2-{4-[N-(1,7-dichloroisoquinolin-3-yl)-N-methylamino]phenoxy}propionate (1.25 g), sodium methoxide (0.63 g) and toluene was heated under reflux for 4 hrs. The mixture was cooled, poured into water and extracted with ethyl acetate. The organic fraction was dried (MgSO4) and evaporated to give 2-{4-[N-(7-chloro-1-methoxyisoquinolin-3-yl)-N-methylamino]phenoxy}propionic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04409017 |
| Source dataset | uspto-grants-1983_10 |
| ORD ID | ord-f9fb191442ab4f8aa4d8c8aa8c19a5f8 |
| Source note | uspto-grants-1983_10 |