HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetamide → 1-[2-(Dimethylamino)-1-(3-trifluoromethylphenoxy)ethyl]cyclohexanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetamide | HCID 178 | — |
| Reactant | 2-[3-(Trifluoromethyl)phenoxy]acetic acid | HCID 1991430 | — |
| Reactant | Borane;tetrahydrofuran | HCID 2723981 | — |
| Reactant | N,N-dimethyl-2-[3-(trifluoromethyl)phenoxy]acetamide | HCID 13672711 | — |
| Product | 1-[2-(Dimethylamino)-1-(3-trifluoromethylphenoxy)ethyl]cyclohexanol | HCID 13672707 | — |
Reaction Steps
N,N-dimethyl-2-[3-trifluoromethyl)phenoxy]acetamide, prepared from 2-[3-trifluoromethylphenoxyl]acetic acid in accordance with Example 1 was converted to the amide which was reduced with Borane/tetrahydrofuran as in Example 3. The title compound was obtained and its hydrochloride salt prepared, m.p. 210°-211° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04609758 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-5586ff239db74521b6835527dab79dc2 |
| Source note | uspto-grants-1986_09 |