Aminoacetamidine Dihydrobromide → 2-Amino-7-propyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine

HRID 647467Notes

Reaction equation

[CH2:1]([N:4]1[CH2:10][CH2:9][C:8](O[Si](C)(C)C)=[C:7](O[Si](C)(C)C)[CH2:6][CH2:5]1)[CH2:2][CH3:3].Br.Br.[NH2:23][CH2:24][C:25]([NH2:27])=[NH:26]>>[NH2:27][C:25]1[CH:24]=[N:23][C:8]2[CH2:9][CH2:10][N:4]([CH2:1][CH2:2][CH3:3])[CH2:5][CH2:6][C:7]=2[N:26]=1

Participants

Reactant 2

HCID 16211382Aminoacetamidine Dihydrobromide

HCID 204364252,3,6,7-Tetrahydro-1-propyl-4,5-bis(trimethylsilyloxy)azepine

Product 1

HCID 130370342-Amino-7-propyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine

Procedure

This compound was prepared analogous to Example 1 from 2,3,6,7-tetrahydro-1-propyl-4,5-bis(trimethylsilyloxy)azepine and 2-amino-acetamidine dihydrobromide.

Sources & evidence

ORD record: ord-6c5f90c9461542f8be48754c1a5ef56e
Source dataset: uspto-grants-1983_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04409220

Reaction notes

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