Sodium amide → HCID 13037032, compound

Participants

Reaction Conditions

Reaction Steps

2.4 gm (0.01 mol) of 7-benzyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine were dissolved in 20 ml of dimethylaniline, 3.9 gm (0.1 mol) of sodium amide were added, and the mixture was heated for four hours at 170° C. Thereafter, the dimethylaniline was distilled off in a high vacuum, the residue was taken up in 4 N sodium hydroxide, and the solution was extracted with chloroform. The chloroform extract solution was dried and column-chromatographically purified on silicagel with methanol/methylene chloride (3:1) as the mobile phase.

Provenance & Evidence