2-Aminoethanimidamide dihydrochloride → 2-Amino-7-cyclobutyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine dihydrochloride

HRID 647479Notes

Reaction equation

HRID 647479 reaction equation
[CH:1]1([N:5]2[CH2:11][CH2:10][C:9](O[Si](C)(C)C)=[C:8](O[Si](C)(C)C)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[ClH:22].Cl.[NH2:24][CH2:25][C:26]([NH2:28])=[NH:27]>>[ClH:22].[ClH:22].[NH2:28][C:26]1[CH:25]=[N:24][C:9]2[CH2:10][CH2:11][N:5]([CH:1]3[CH2:4][CH2:3][CH2:2]3)[CH2:6][CH2:7][C:8]=2[N:27]=1

Participants

3

Reactant 2

HCID 189434792-Aminoethanimidamide dihydrochlorideHCID 204364371-Cyclobutyl-2,3,6,7-tetrahydro-4,5-bis(trimethylsilyloxy)-azepine

Product 1

HCID 204364342-Amino-7-cyclobutyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine dihydrochloride

Procedure

This compound was prepared analogous to Example 22 from 1-cyclobutyl-2,3,6,7-tetrahydro-4,5-bis(trimethylsilyloxy)-azepine and α-amino-acetamidine dihydrochloride.

Sources & evidence

ORD record
ord-296cc1ab6be445a58758f4f400114d65
Source dataset
uspto-grants-1983_10
Patent number
US04409220

Reaction notes

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