2-Aminoethanimidamide dihydrochloride → 2-Amino-7-(3-phenyl-propyl)-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine dihydrochloride

HRID 647480Notes

Reaction equation

HRID 647480 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:16][CH2:15][C:14](O[Si](C)(C)C)=[C:13](O[Si](C)(C)C)[CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:27].Cl.[NH2:29][CH2:30][C:31]([NH2:33])=[NH:32]>>[ClH:27].[ClH:27].[NH2:33][C:31]1[CH:30]=[N:29][C:14]2[CH2:15][CH2:16][N:10]([CH2:9][CH2:8][CH2:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH2:11][CH2:12][C:13]=2[N:32]=1

Participants

3

Reactant 2

HCID 189434792-Aminoethanimidamide dihydrochlorideHCID 204364331-(3-Phenyl-propyl)-2,3,6,7-tetrahydro-4,5-bis(trimethylsilyloxy)-azepine

Product 1

HCID 204364172-Amino-7-(3-phenyl-propyl)-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine dihydrochloride

Procedure

This compound was prepared analogous to Example 22 from 1-(3-phenyl-propyl)-2,3,6,7-tetrahydro-4,5-bis(trimethylsilyloxy)-azepine and α-amino-acetamidine dihydrochloride.

Sources & evidence

ORD record
ord-7e07ca2dd1c34ae2a59dbe8163ac6c0f
Source dataset
uspto-grants-1983_10
Patent number
US04409220

Reaction notes

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