2-Aminoethanimidamide dihydrochloride → 2-Amino-5(R,S),7,9(R,S)-trimethyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine dihydrochloride

HRID 647481Notes

Reaction equation

HRID 647481 reaction equation
[CH3:1][N:2]1[CH2:8][CH:7]([CH3:9])[C:6](O[Si](C)(C)C)=[C:5](O[Si](C)(C)C)[CH:4]([CH3:20])[CH2:3]1.[ClH:21].Cl.[NH2:23][CH2:24][C:25]([NH2:27])=[NH:26]>>[ClH:21].[ClH:21].[NH2:27][C:25]1[CH:24]=[N:23][C:6]2[CH:7]([CH3:9])[CH2:8][N:2]([CH3:1])[CH2:3][CH:4]([CH3:20])[C:5]=2[N:26]=1

Participants

3

Reactant 2

HCID 189434792-Aminoethanimidamide dihydrochlorideHCID 204363971,3(R,S),6(R,S)-trimethyl-2,3,6,7-tetrahydro-4,5-bis(trimethylsilyloxy)-azepine

Product 1

HCID 204363822-Amino-5(R,S),7,9(R,S)-trimethyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine dihydrochloride

Procedure

This compound was prepared analogous to Example 22 from 1,3(R,S),6(R,S)-trimethyl-2,3,6,7-tetrahydro-4,5-bis(trimethylsilyloxy)-azepine and α-amino-acetamidine dihydrochloride.

Sources & evidence

ORD record
ord-e67a072eae68452e916da4abe107d868
Source dataset
uspto-grants-1983_10
Patent number
US04409220

Reaction notes

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