2,3-Dichloropyridine → HCID 20485174, compound

HRID 647507Notes

Reaction equation

[C:1]([NH:4][CH:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)(=[O:3])[CH3:2].Cl[C:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][N:13]=1>>[C:1]([NH:4][CH:5]1[CH2:10][CH2:9][NH:8][CH:7]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][N:13]=2)[CH2:6]1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 169882,3-Dichloropyridine

HCID 14451564-Acetamidopiperidine

Product 1

HCID 20485174HCID 20485174, compoundYield 70%

Procedure

Following the modus operandi described in Example 1, by reaction of 4-acetamidopiperidine with 2,3-dichloropyridine, 4-acetamido-2-(3-chloropyridyl)piperidine is obtained, with a yield of 70%, which, after crystallization in ethyl acetate, melts at 118° to 120° C. By hydrolysis of the product thus obtained with 6 N hydrochloride acid, the monohydrochloride of 4-amino-1-(3-chloropyridyl)piperidine (CM 57375) is obtained which is crystallised in 90% ethanol; m.p. 258° to 260° C. with decomposition.

Sources & evidence

ORD record: ord-4b253b2ae15f449aa82535f055324101
Source dataset: uspto-grants-1983_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04409228

Reaction notes

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