Sodium Hydroxide → 5-[(2-Cyanoaziridin-1-yl)methyl]thiophene-2-carboxylic acid

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Reaction Steps

95 ml. 0.1 N Aqueous sodium hydroxide solution are added dropwise, with stirring, to 2.1 g. 2-cyano-1-(5-methoxycarbonyl-2-thenyl)-aziridine (see Example 13a) in 21 ml. acetone. When no more ester can be detected by thin layer chromatography, the reaction mixture is evaporated in a vacuum, acidified with dilute hydrochloric acid and extracted with ethyl acetate. The evaporation residue is crystallized with diethyl ether. There is obtained 1.2 g (61% of theory) 2-cyano-1-(5-carboxy-2-thenyl)-aziridine; m.p. 108°-111° C. The sodium salt melts with decomposition at 238°-243° C.

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