Phenyl chloroformate → HCID 12694091, compound

Participants

Reaction Steps

A mixture of 3-(4-fluorophenyl)-1,3-dihydro-1'-methylspiro[benzo(c)thiophene-1,4'-piperidine] of Example 27 (3.6 g), 2.1 g of phenyl chloroformate in 100 ml of CH2Cl2 is stirred at room temperature for 64 hours. The solution is washed with 10% aqueous NaOH, water, and dried over MgSO4. Evaporation under reduced pressure affords a crystalline residue, m.p. 198°-200° C. Recrystallization of the crude product from acetone-pentane gives granular crystals, m.p. 200°-201° C. for 3-(4-fluorophenyl)-1,3-dihydro-1'-phenoxycarbonylspiro[benzo(c)thiophene-1,4'-piperidine].

Provenance & Evidence