Thionyl Chloride → HCID 20485210, compound

In 15 ml of dry benzene were dissolved 1.8 g of α-(2,2-dichlorovinyl)isovaleric acid, followed by the addition of 3.5 g of thionyl chloride. The mixture was refluxed for 5 hours and, then, distilled to remove the low-boiling fraction. By the above procedure there was obtained α-(2,2-dichlorovinyl)isovaleroyl chloride. This chloride was dissolved in 20 ml of benzene, and 2.0 g of α-ethynyl-3-phenoxybenzyl alcohol were added. This was followed by the addition of 2.9 g of pyridine and the mixture was stirred at room temperature for 8 hours. The resultant reaction mixture was diluted with diethyl ether, washed with water and dilute aqueous hydrogen chloride and dried over anhydrous magnesium sulfate. The low-boiling fraction was then distilled off and the residue was chromatographed on a column of silica gel (benzene/n-hexane=1:1 v/v). By the above procedure there were obtained 2.6 g of α-ethynyl-3-phenoxybenzyl α-(2,2-dichlorovinyl)isovalerate (compound [2]) having the following properties [yield: 71% based on α-(2,2-dichlorovinyl)isovaleric acid].

1. temperatureThe mixture was refluxed for 5 hours
2. distillationdistilled
3. customto remove the low-boiling fraction

ORD record

ord-861fd8182053465ca9ea262c1347f5de

Source dataset

uspto-grants-1983_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04409238