Hydroxyamine hydrochloride → HCID 54186551, compound

Participants

Reaction Conditions

Reaction Steps

An aqueous solution of hydroxylamine is prepared from 39.06 g (0.562 mol) of hydroxylamine hydrochloride in 150 ml of water and from 56.2 g (0.562 mol) of potassium bicarbonate. 48.9 g (0.225 mol) of 4-(o-allylphenoxy)-3-hydroxy-butyronitrile previously dissolved in 250 ml of n-butanol are then added. The resulting mixture is taken to 80° C. in about 2 hours, then taken to reflux (94° C.) which is maintained for 5 hours. The mixture is cooled, the H2O--CH3 (CH2)2CH2OH mixture is evaporated, the residue of evaporation is taken up with ether, washed several times in water, dried and the ether is evaporated under reduced pressure. 48.5 g (yield 86%) of 4-(o-allyl-phenoxy)-3-hydroxy-butyramidoxime are obtained in the form of a brown oil.

Provenance & Evidence