Thionyl Chloride → HCID 20483193, compound

Participants

Reaction Steps

185.8 g thionylchloride are added to 190 g 1,2,3,4-tetrahydro-2-[N-(3-hydroxypropyl)-N-propylamino]-5-methoxy-naphthalene (free base) in 1.5 liters chloroform. The resultant warm reaction mixture is refluxed for 1 hour, and after concentration partitioned between methylene chloride and 2 N sodium hydroxide. The organic phase is washed with water, dried over sodium sulphate, filtered and concentrated. The crude heading compound so obtained is converted into the bis[base]naphthalene-1,5-disulphonate. M.pt. 239°-242° (decomp).

Provenance & Evidence