反应详情

A mixture of 2,2,2-trichloroethyl 6-(2-phenylacetamido)-2-methyl-2-bromomethylpenam-3-carboxylate (0.54 g.), chloroform (5 cc) and pyridine (0.16 g.) was heated under reflux for 2.5 hours. The reaction mixture was washed with water, dried over magnesium sulfate and then concentrated. The residue was crystallized from ether to yield crystals (0.34 g.) of 2,2,2-trichloroethyl 7-(2-phenylacetamido)-3-methyl-3-cephem-4-carboxylate, m.p. 161°-162° C.

1. temperaturewas heated
2. temperatureunder reflux for 2.5 hours
3. washThe reaction mixture was washed with water
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated
6. customThe residue was crystallized from ether