Cyclopropanecarbonyl chloride → 6-(p-cyclopropylcarbonylaminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone

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Reaction Steps

6.0 g (29.5 millimoles) of 6-(p-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone, 3.4 g (32.5 millimoles) of cyclopropanecarboxylic acid chloride and 100 ml of absolute toluene are kept for 6 hours at 80° C. The product is filtered off at 10° C., washed first with toluene and then with water, and recrystallized from dimethylformamide/water. 6.8 g (85% of theory) of 6-(p-cyclopropylcarbonylaminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone are obtained as beige crystals, of melting point 267°-268° C.

Provenance & Evidence