Ici 109,081 → HCID 20483374, compound

Participants

Reaction Conditions

Reaction Steps

6.0 g (29.5 millimoles) of 6-(p-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone are dissolved in 150 ml of absolute tetrahydrofuran by stirring and heating to 60° C. 4.2 g (35.4 millimoles) of 1-methylcyclopropanecarboxylic acid chloride are added dropwise to the above solution at 60° C., and the reaction mixture is then stirred for 7 hours at the reflux temperature. The product is filtered off at 10° C., washed with water and recrystallized twice from dimethylformamide/water. 5.5 g (65% of theory) of 4,5-dihydro-5-methyl-6-[p-(1-methylcyclopropylcarbonylamino)-phenyl]-3(2H)-pyridazinone are obtained as almost colorless crystals, of melting point 235°-237° C.

Provenance & Evidence