6-(4-Aminophenyl)-4,5-dihydropyridazin-3(2H)-one → HCID 53950990, compound

Participants

Reaction Steps

4.0 g (21.1 millimoles) of 6-(p-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone of trans-2-bromocyclopropanecarboxylic acid chloride, 4.3 g (23.4 millimoles) and 100 ml of absolute tetrahydrofuran are kept for 20 hours at room temperature and then refluxed for 6 hours. The product is filtered off at 10° C., washed with water and recrystallized from dimethylformamide/water. 4.1 g (58% of theory) of trans-6-[p-(2-bromocyclopropylcarbonylamino)-phenyl]-4,5-dihydro-3(2H)-pyridazinone are obtained as colorless crystals, of melting point 260°-261° C. (with decomposition).

Provenance & Evidence