Methyl chloroformate → 4,9-dihydro-4-methoxycarbonyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

HRID 647816Notes

Reaction equation

HRID 647816 reaction equation
[CH:1]1[S:2][CH:3]=[C:4]2[C:10]=1[C:9](=[O:11])[NH:8][C:7]1[CH:12]=[CH:13][CH:14]=[CH:15][C:6]=1[NH:5]2.[C:16](Cl)(=[O:19])[O:17][CH3:18]>O1CCOCC1.C1(C)C=CC=CC=1>[CH3:18][O:17][C:16]([N:5]1[C:6]2[CH:15]=[CH:14][CH:13]=[CH:12][C:7]=2[NH:8][C:9](=[O:11])[C:10]2=[CH:1][S:2][CH:3]=[C:4]12)=[O:19]

Participants

5

Reactant 2

HCID 6586Methyl chloroformateHCID 125216414,9-dihydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

Product 1

HCID 204833214,9-dihydro-4-methoxycarbonyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 312751,4-DioxaneSolvent

Procedure

From 4,9-dihydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and methyl chlorocarbonate in a mixture of dioxane and toluene, 4,9-dihydro-4-methoxycarbonyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one was obtained;

Sources & evidence

ORD record
ord-16d6986b7b7b4d1fb20eb55131f52a6c
Source dataset
uspto-grants-1983_10
Patent number
US04410527

Reaction notes

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