反应详情

In this reference example, 1.67 g of 1-benzyl-4-(2-nitroanilino)-piperidine hydrochloride is suspended in 30 ml of dioxane. The suspension is mixed with 13 ml of acetyl bromide and refluxed for 4 hours. The resultant reaction mixture is cooled and then the deposited crystals are separated by filtration. The crystals are washed with ether and then dried to obtain 1.96 g of crude crystals. The crude crystals are recrystallized from 25 ml of ethanol to obtain 1.33 g of the desired product.

1. temperaturerefluxed for 4 hours
2. customThe resultant reaction mixture
3. temperatureis cooled
4. customthe deposited crystals are separated by filtration
5. washThe crystals are washed with ether
6. customdried
7. customto obtain 1.96 g of crude crystals
8. customThe crude crystals are recrystallized from 25 ml of ethanol